Although there have been many advances in monitoring techniques, severe ovarian hyperstimulation syndrome (OHSS) still occurs approximately in 1% of patients treated with ovulation induction agents in assisted reproductive technology(ART)
program.
The
pathogenesis of OHSS is unclear, but the proposed mechanism is the production of vasoactive substances resulting in the increased local capillary permeability and the fluid shift from the intravascular space into the third space. This fluid shift
into
the third space may cause ascites, hypovolemia, oliguria, hemoconcentration, thromboembolism, and even death. Most clinicians regard thromboembolism as the most severe form of OHSS. The etiological factors implicated in thromboembolism in OHSS
are
the
increased blood viscosity due to hemoconcentration, the alteration in coagulation factors, the venous compression due to enlarged ova-ries and ascites, and the immobilization of patients.
We have experienced a case of severe OHSS with a complication of cerebrovascular thromboembolism in in vitro fertilization (IVF) patient and present it with the review of literature.
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